Cancer Cell. with 100 nM of progesterone, MDM2 p90 was inhibited but the highly expressed MDM2 p57 F2rl1 isoform was not. The inhibition of MDM2 p90 protein by progesterone was abrogated in MCF-7 cells transfected with a P53 expressing vector. To our knowledge, this is the first report linking progesterone-induced growth inhibition with down-regulation of … Continue reading Cancer Cell